Nobiletin and CaSR
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The HPH rat model was constructed by 6-weeks consecutive hypoxia. Nobiletin or Sildenafil was administered daily via gavage for a duration of 2-weeks. Subsequently, hemodynamic parameters, HE staining and Masson staining, cytoplasmic calcium level of pulmonary arterial smooth muscle cells (PASMCs) were measured. Additionally, cellular thermal shift assays (CETSA), cell migration and proliferation assays, and immunoblotting were performed to explore the therapeutic effects and underlying mechanisms of Nobiletin on HPH in rats.
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Science Data Bank创建时间：
2024-09-26
