An axonal guidance cue Semaphorin 6D orchestrates systemic metabolism and myelopoiesis through tuning sympathetic innervation. An axonal guidance cue Semaphorin 6D orchestrates systemic metabolism and myelopoiesis through tuning sympathetic innervation

The goal of this study is to characterize the molecular basis for enhanced myelopoiesis in Sema6d-/- mice fed a high fat diet. Overall design: WT and Sema6d-/- mice were fed with either control or high fat diet for 3 months. Hematopoietic stem cells and multipotent progenitors were sorted from the bone marrow.