Integrative single-cell and spatial transcriptomic analyses identify a pathogenic cholangiocyte niche and TNFRSF12A as therapeutic target for biliary atresia. Integrative single-cell and spatial transcriptomic analyses identify a pathogenic cholangiocyte niche and TNFRSF12A as therapeutic target for biliary atresia

We performed single cell 5' RNA sequencing, and B cell receptor and T cell receptor V(D)J sequencing analyses on liver biopsies of nine patients with biliary atresia and three patients with choledochal cyst at diagnosis to generate the liver cell atlas. Overall design: Single cell 5' RNA sequencing and V(D)J sequencing analyses of liver biopsies from nine patients with biliary atresia and three patients with choledochal cyst were collected at the time of diagnosis. 10x Genomics Chromium Next GEM Single Cell 5' RNA-seq and single cell V(D)J sequencing. **Submitter declares that the raw data have not been provided due to patient privacy concerns**