Expression data from AEG-1fl/fl and AEG-1DHEP mice which have conditional hepatocyte-specific knockout of AEG-1 (Astrocyte elevated gene 1)

AEG-1 is overexpressed in human hepatocellular carcinoma (HCC) and positively regulates development and progression of HCC A conditional hepatocyte-specific knockout mouse was generated by crossing floxed AEG-1 mouse with Alb/Cre mouse in C57BL/6 background Livers were harvested from chow-fed 12 wks old AEG-1fl/fl and AEG-1DHEP mice. RNA was extracted and subjected to RNA-Seq.AEG-1在人类肝细胞癌（hepatocellular carcinoma, HCC）中过表达，并正向调控肝细胞癌的发生与进展。本研究通过将C57BL/6背景下的floxed AEG-1小鼠与Alb/Cre小鼠杂交，构建了条件性肝细胞特异性敲除小鼠。随后，采集正常饲料喂养的12周龄AEG-1fl/fl与AEG-1DHEP小鼠的肝脏组织，提取总RNA并开展RNA测序（RNA-Seq）实验。