Crystal structure of human Aldose Reductase complexed with NADP+ and JF0064

Crystal structure of human Aldose Reductase complexed with NADP+ and JF0064 Descriptor: 2,2',3,3',5,5',6,6'-octafluorobiphenyl-4,4'-diol, Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE Authors: Cousido-Siah, A, Ruiz, F.X, Mitschler, A, Porte, S, de Lera, A.R, Martin, M.J, de la Fuente, J.A, Klebe, G, Farres, J, Pares, X, Podjarny, A. Deposit date: 2012-12-18 Release date: 2014-03-19 Last modified: 2023-09-20 Method: X-RAY DIFFRACTION (0.85 Å) Cite: Identification of a novel polyfluorinated compound as a lead to inhibit the human enzymes aldose reductase and AKR1B10: structure determination of both ternary complexes and implications for drug design. Acta Crystallogr.,Sect.D, 70, 2014