Physical Barrier Combined with Estrogen or Small Intestinal Submucosa Prevents Intrauterine Adhesions after Hysteroscopic Adhesiolysis

Study objective:
To evaluate the efficacy of two advanced barriers small intestinal submucosa (SIS) scaffold and intrauterine stent carrying estrogen versus traditional methods for the prevention of adhesion and pregnancy rate improvement in infertile women with moderate to severe intrauterine adhesion (IUAs).
Design: Prospective study.
Setting：Beijing Tiantan Hospital Affiliated to Capital Medical University.
Patients: Patients who were diagnosed with moderate-to-severe IUAs at Beijing Tiantan Hospital between June 2021 and February 2024.
Intervention: Patients were randomly divided into advanced group or traditional group, and each group was randomly divided into 2 subgroups to receive different methods: SIS scaffold (n=33) and intrauterine stent (n=37) in the advanced group, hyaluronic acid (n=33) and Foley balloon (n=32) in the traditional group. Except the intrauterine stent group, all patients received estrogen treatment.