Single-cell RNA Sequencing Dataset of Peripheral Blood Immune Cells from Individuals with Rheumatoid Arthritis

Full Dataset DescriptionThis dataset is associated with the research findings published in Science Translational Medicine.Please cite the original published article when reusing this dataset: He Z, Glass MC, Venkatesan P, et al. Progression to rheumatoid arthritis in at-risk individuals is defined by systemic inflammation and by T and B cell dysregulation. Science Translational Medicine, 2025, 17(794): eadt7214.Early RA (ERA) group: 11 cases;Healthy Control Group 1 (CON1): 38 cases.Gene Expression Matrix File: Single-cell gene-cell expression matrix in H5 format.Data Storage and Access: This is a public dataset and no additional ethical compliance is required. The raw sequencing data have been deposited in the GEO database (accession number: GSE274680). The raw fastq files are stored in the dbGap database (accession number: phs003944.v1.p1). The processed analysis files and supporting codes are available via the Dryad database (DOI: 10.5061/dryad.1rn8pk13z).Ethical Compliance of the Original Dataset: All participants in the original study provided written informed consent. The study protocol was approved by the Institutional Review Boards of the University of California, San Diego, the University of Colorado Anschutz Medical Campus, and the Benaroya Research Institute.