The #mutations and percentage of deleterious mutations for published methods.

a39887 disease mutations from PMD database, 13990 neutral mutations from PMD and 26840 neutral mutations from residues that differed in pairwise alignments of enzymes with experimentally annotated similarity in function and the same EC numbers.bDerived from the Swiss-Prot release 48 (Dec 2005).cIncludes only mutations from protein sequence deposited in Swiss-Prot from January to November 2006 (release 51).dThe neutral mutations are extracted from LacI.eThe neutral mutations are extracted from the evolutionary model.fStructure-based case.gAvailable at http://gpcr2.biocomp.unibo.it/~emidio/PhD-SNP/OutPhD-SNP08.txt.hThe data set of SNAP.i3155 damaging alleles annotated in the Uniprot database as causing human Mendelian diseases and affecting protein stability or function, 6321 differences between human proteins and their closely related mammalian homologs, assumed to be nondamaging.j13032 human disease-causing mutations from UniProt and 8946 human nonsynonymous single-nucleotide polymorphisms without annotated involvement in disease.