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An N-Heterocyclic Carbene-Catalyzed [8 + 3] Annulation of Tropone and Enals via Homoenolate

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NIAID Data Ecosystem2026-03-06 收录
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https://figshare.com/articles/dataset/An_N_Heterocyclic_Carbene_Catalyzed_8_3_Annulation_of_Tropone_and_Enals_via_Homoenolate/3048721
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资源简介:
A novel protocol for the annulation of tropone to enals involving nucleophilic heterocyclic carbene (NHC) catalyzed homoenolate formation has been developed. Interestingly, the reaction led to bicyclic δ-lactones instead of the expected γ-spirolactones, presumably by the uncommon [8 + 3] annulation pathway. The strategy works well with a variety of enals.
创建时间:
2016-02-29
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