Novel mechanism of MYC deregulation in Multiple Myeloma

MYC deregulation occurs in 67% of MM cases and is associated with progression and worse prognosis in Multiple Myeloma (MM). Enhanced MYC expression is known to be driven by translocation or amplification events, but it only occurs in 40% of patients of MM. Here, we sought to explore the mechanisms aberrant high MYC expression can occur in the absence of translocations or amplifications. Together, our findings define a new epigenetic mechanism of MYC deregulation inMM beyond known translocations or amplifications and point to the importance of non-coding regulatory elements and their associated transcription factor networks as drivers of MM progression.