One-Pot, Three-Component Synthesis of 5‑Sulfenyl-2-iminothiazolines by Cross-Dehydrogenative C–S Coupling Using I₂/DMSO in Open Air

A one-pot, three-component, transition-metal-free regioselective sulfenylation of 2-iminothiazoline through the cross-dehydrogenative coupling strategy via sp2 C–H functionalization has been developed employing iodine as a catalyst and dimethyl sulfoxide as an oxidant. Utility of this sulfenylation technique has been well depicted through participation of various aryl and heterocyclic thiols. Significant features of this C–H functionalization strategy include metal-free open air reaction conditions, which offer a mild and efficient method for sulfenylation to achieve diversely substituted 5-sulfenyl-2-iminothiazoline derivatives.