Changes in the level of clinical and renal parameters induced by transduction of Tat-fusion proteins for 16 weeks.

Diabetic OLETF rats were randomly divided into two groups, a Tat-GFP treatment group and a Tat-MT-Tat-SOD combination treatment group. The former were injected every 3 days with 3 mg/kg of Tat-GFP, and the latter with 3 mg/kg of Tat-MT and 3 mg/kg of Tat-SOD. The fusion protein treatment continued for 16 weeks. LETO rats were used as histological controls. Urinary protein levels were determined by the Bradford method and microalbumin levels were measured with a microalbumin quantitation ELISA kit (Bethyl Laboratories, Montgomery, TX).Values are expressed as means±SEM.*p**p†p‡ p#p##p$p$$pAbbreviations; TGFP: Tat-GFP, TMTS: Tat-MT-Tat-SOD combination.Changes in the level of clinical and renal parameters induced by transduction of Tat-fusion proteins for 16 weeks.