Representative confocal line scan data and kymographs for an isogenic trio of c.MYH7C9123T R-GECO1.0 expressing hiPSC-CMs at day 30 and an isogenic pair of c.ACTC1G301A R-GECO1.0 expressing hiPSC-CMs
For definitions of the lengths, see Fig 1C. Note that Li denotes the length from the membrane of the T-tubule to the membrane of the SR (dyad width), and will be used as a control parameter in computa
Calpains are calcium (Ca2+) activated neutral proteases that are involved in several essential signaling pathways. One Calpain-specific proteolytic target is Junctophilin-2 (JP2), an important structu
BackgroundThe ability to establish human induced pluripotent stem cells (hiPSCs) by reprogramming of adult fibroblasts and to coax their differentiation into cardiomyocytes opens unique opportunities
Intracellular calcium signals are studied by laser-scanning confocal fluorescence microscopy. The required spatio-temporal resolution makes description of calcium signals difficult because of the low
