EVALUATION OF ANTIDEPRESSANT ACTIVITY IN CENTRAL NERVOUS SYSTEM OF MICE MODEL USING AQUEOUS EXTRACT OF DIGERA MURICATA

The aim of the present study was to evaluate some effects of Digera muricata (DM) on central<br>nervous system. The effects of Aqueous Extracts of Digera muricata (AEDM) tested with<br>Neuropharmacological activities like acute toxicity, spontaneous motor activity, exploratory behavioral<br>pattern, marble burying and tail suspension tests were studied in Albino mice. In acute toxicity mice were<br>administered with AEDM and MEDM doses orally at 50, 100 and 200 mg/kg body weight<br>intraperitoneally respectively, were tested in mice using different standards like 4 mg diazepam/kg, 3 mg<br>chlorpromazine and 3 mg imipramin/kg -induced sleep test.