Inhibition of mTORC1 reduces fibrotic gene expression

Organism: House mouse Experiment type: Expression profiling by high throughput sequencing Summary CONTEXT: Epididymal adipose tissue (EAT) transcriptome studies provide holistic pictures of ob/ob mice with or without rapamycin. OBJECTIVE: To implement EAT gene expression profiling and investigate the link between changes in AT gene expression of ob/ob mice with or without rapamycin. RESULTS: Rapamycin, the inhibitor of mTORC1, reduces fibrotic gene expression.