The structures of the allosteric process.

The average structures are extracted from the trajectories of the O-eIF4A, ATP+eIF4A, I, II, III, IV and ATP+RNA+C-eIF4A models involved in the allosteric process of the ATP binding followed by RNA, i.e., the ATP+eIF4A model for the ATP first binding to the O-eIF4A model; the I-IV models for the RNA second binding to the equilibrium structure of the ATP+eIF4A model; the ATP+RNA+C-eIF4A model for the closed state of the eIF4A protein. The center image shows the time-dependence of the mass center distance between two domains (black), and that of N-domain – C-domain interface (red) during the simulation.