We systematically mapped the sequence space of the four key specificity residues in the Escherichia coli histidine kinase PhoQ. The cells were selected using FACS with a transcriptional reporter and m

NIAID Data Ecosystem40

Deep mutational scanning of CYP2C19 reveals a substrate specificity-abundance tradeoff. Deep mutational scanning of CYP2C19 reveals a substrate specificity-abundance tradeoff

药物代谢酶

蛋白质深度突变扫描

Cytochrome P450s (CYPs) are a family of enzymes responsible for metabolizing nearly 80% of small molecule drugs. Variants in CYPs can substantially alter drug metabolism, which may result in improper

NIAID Data Ecosystem30

Deep mutational scanning of essential bacterial proteins can guide antibiotic development

抗生素靶点

蛋白质深度突变扫描

Deep mutational scanning is a powerful approach to investigate a wide variety of research questions including protein function and stability. We performed deep mutational scanning on three essential E

NIAID Data Ecosystem70

Summary of the five proteins and DMS datasets, ordered in decreasing percentage of sequence space coverage in the dataset.

蛋白质深度突变扫描

蛋白质功能预测

Summary of the five proteins and DMS datasets, ordered in decreasing percentage of sequence space coverage in the dataset.

Figshare2026-03-25 更新40