Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1

Ankyrins link both L1 and ion channel proteins, coupling them to the spectrin actin cytoskeleton. In the nervous system ankyrins interact with voltage gated channels and cluster them in axon initial segments to generate action potentials. At these points the actin spectrin network is linked via ankyrins to voltage gated sodium channels, L1, and the voltage gated potassium ion channel subunits, KCNQ2 and KCNQ3.

ankyrin 蛋白不仅与 L1 和离子通道蛋白相连接，而且将它们耦合至 spectrin-actin 细胞骨架。在神经系统内，ankyrin 与电压门控通道相互作用，并将它们聚集在轴突起始段以产生动作电位。在这些位置，actin-spectrin 网络通过 ankyrin 与电压门控钠通道、L1 以及电压门控钾离子通道亚基 KCNQ2 和 KCNQ3 相联系。