C57BL/6 mice intratracheally infected with 6×10³ copies of PVM develop clinical signs, increased alveolar permeability and pulmonary edema.

A: mean clinical scores (left y-axis, line) and weight loss (right y-axis, bar) during infection with PVM. B: lung wet-to-dry weight ratio of C57BL/6 mice during PVM infection. C: IgM concentration in bronchoalveolar lavage fluid (BALF) of PVM-infected C57BL/5 mice. The graphs represent the mean of 4 mice at each time-point (± SEM). **p<0.01, ***p<0.001, as compared to uninfected mice (t = 0).