Cripto shapes macrophage plasticity and restricts EndMT in injured and diseased skeletal muscle
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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The membrane protein Cripto plays a key role in shaping macrophage plasticity in skeletal muscle during regeneration and disease. Cripto acts as an extrinsic modulator of macrophage plasticity and is required for the proper expansion/maintenance of the CD206+ anti-inflammatory macrophage population. Nevertheless, Cripto deletion does not change the gene expression profile of F4/80+/Ly6CLow macrophages suggesting that Cripto was dispensable to induce/maintain the Ly6CLow phenotype.
提供机构:
UPF
创建时间:
2022-02-20



