Crystal structure of PLK1 in complex with a pyrimidodiazepinone inhibitor
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Crystal structure of PLK1 in complex with a pyrimidodiazepinone inhibitor Descriptor: 4-{[(7R)-9-cyclopentyl-7-ethenyl-7-fluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl]amino}-3-methoxy-N-(4-methylpiperazin-1-yl)benzamide, ACETATE ION, Serine/threonine-protein kinase PLK1, ... Authors: Hosfield, D.J, Skene, R.J. Deposit date: 2013-02-07 Release date: 2013-05-29 Last modified: 2024-02-28 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1). Bioorg.Med.Chem.Lett., 23, 2013
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2013-02-07
