Single cell RNA-sequencing reveals an important role of SRSF1 and SRSF2 in the development of diabetes.

Single-cell sequencing of islet cells from WT , ASF knock-out, SC35 knock-out mice reveals different mechanisms of diabetes formation and development. Overall design: The pancreases of 9-month-old WT , ASF-KO and SC35-KO mice were perfused with collagenase, and islet cells were isolated and digested into single cell for single-cell RNA-sequencing.