PRMT6 inhibitors promote fracture healing by modulating osteoclast glucose metabolism

Lack of clinical treatment for impaired fracture healing Due to the complexity of the fracture healing process. Osteoclasts, formed by monocytes, play a key role in the fracture healing process. However, there is still a lack of effective clinical tools to promote fracture healing by regulating osteoclasts due to their complex function in bone tissue reconstruction. Our study revealed that Protein Arginine Methyltransferase 6 (PRMT6) is involved in fracture healing by modulating osteoclast glucose metabolism. The present study found that PRMT6 promotes osteoclastogenesis and activates glycolysis. In contrast, PRMT6 deficiency or inhibition reversed this phenomenon.Further, we demonstrated that PRMT6 inhibitors can effectively promote fracture healing by inhibiting osteoclast formation. Our work provides new ideas for clinical treatment of impaired fracture healing. Meanwhile, our work provides new clues for understanding bone tissue regeneration.