RNA-seq analysis of dolastatin 15 treatment in HCT116 cells. RNA-seq analysis of dolastatin 15 treatment in HCT116 cells
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Dolastatin 15 is a known tubulin binding agent and shows remarkable differential cytotoxicity against a panel of colorectal HCT116 isogenic cells. The compound causes anti-vascularization effect in human endothelial cells (HUVEC) in a dose dependent manner. Antiangiogenic effect was further validated in a zebrafish genetic model with activated HIF Overall design: Examination of Dolastatin 15 effect on HCT116 cells relative to solvent controls using two different concentrations of 20 nM and 100 nM at 16 and 24 hour time points
创建时间：
2019-03-23
