Comparison of estimated effect sizes for early versus advanced AMD for published SNPs showing genome-wide significant association with AMD.

aSuperscript shows reference for the largest study reporting genome-wide association of the relevant SNP with AMD:1Chen et al, 2010 11.2Yu et al, 2011 15.3Klein et al, 2005 12.4Kopplin et al, 2010 13.5Arakawa et al, 2011 10.6Neale et al, 2010 14.bNCBI Human Genome Build 36.3 coordinates;cEffective allele;dFrequency of the effective allele;eSummary meta-analysis regression coefficient, indicating the overall, estimated change in log(odds) associated with each additional copy of the effective allele;fEstimated odds ratio and 95% confidence interval for each additional copy of the effective allele, based on fixed-effects meta-analysis of European-ancestry cohorts;gP-value associated with the estimated OR;hHeterogeneity P-value, based on Cochran’s Q statistic;iP-value from test of heterogeneity of regression coefficients between early and advanced AMD. The threshold for study-wise significance was 0.0024, after accounting for multiple tests. Significant results are shown in bold;jRatio of regression coefficient for advanced vs early AMD, formulated as Betaadv/Betaearly.Notes: This study did not have data and could not assess association for additional published SNPs rs4711751 in VEGFA and rs11200638 in HTRA1.