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The base editor for programming larger C to U (T) scope (BE-PLUS)

NIAID Data Ecosystem2026-03-11 收录

碱基编辑

C-to-T编辑

数据链接：

https://www.omicsdi.org/dataset/node/OEX00001432 数据链接链接失效反馈

官方服务：

资源简介：

The base editor for programming larger C to U (T) scope (BE-PLUS)

应用场景：

创建时间：

2019-05-30

碱基编辑

CRISPR-Cas9

Base editors, which are created through fusion of Cas9 nickase to either cytidine or adenine deaminase, efficiently catalyze site-specific nucleotide conversions with minimal indel rates1, 2. However,

NIAID Data Ecosystem50

A-T to G-C base editing efficiency at targeted gene sites in HEK293T cell line

碱基编辑

基因编辑工具评估

A-T to G-C base editing efficiency at targeted gene sites in HEK293T cells using the dCas12f-ABE design or the Cas12f-ABE design. Found that the total A-T to G-C conversion efficiency of Circular gRNA

NIAID Data Ecosystem30

GO: A functional reporter system to identify and enrich base editing activity

碱基编辑

基因工程工具开发

This study developed tools for enriching base editing events in mouse and human cell lines

NIAID Data Ecosystem20

Programmable RNA base editing with a single engineered protein

碱基编辑

基因治疗

Programmable base editing of RNA enables rewriting the genetic codes on specific sites. Current tools for specific RNA editing dependent on the assembly or recruitment of the guide RNA into an RNA/pro

NIAID Data Ecosystem40

dual gRNA system achieve efficient C-to-T&G-to-A,A-to-G&T-to-C base editing

基因编辑

碱基编辑

dual gRNA system achieve efficient C-to-T&G-to-A,A-to-G&T-to-C base editing

NIAID Data Ecosystem30