Peromyscus WGCNA supplement

P. leucopus also (deer mouse) is a known reservoir for infectious disease
such as lyme disease and it is able to survive infections that other
rodent models cannot. In this paper we explore P. lecucopus transcriptomic
response after LPS stimulus in blood, liver and spleen using RNA-seq and
compare it to M. musculus response. When comparing gene response to LPS
from different species and tissues, neutrophil associated terms are
enriched in the P. leucopus response, while mouse response is enriched for
cytokine signaling. To compare intra species and tissue gene patterns, we
identified gene networks that were associated with specie specific
upregulation response to LPS. Interestingly majority of the genes that
were upregulated in P. leucopus response originated from blood, whereas
most of the M. musculus genes originated from liver. Both of these gene
modules uphold the Neutrophil associated pathways for P. leucopus and
cytokine mediated response for mouse that originated from independent
analysis. We characterized and identify key genes for LPS response in P.
leucopus and M. musculus, additionally we identify biological processes
characteristic for each specie that pointed to inflammation, oxidative
stress, phagocytosis, and metabolism. Thanks to its robust immune response
and alternative pathways, P. leucopus stands out as a novel model to
evaluate a broader range of infectious diseases.