CD8⁺ T cell responses specific for ts-derived peptides with high representation in the <i>T. cruzi</i> genome in HLA-A2.1⁺ patients with chronic Chagas disease, measured by IFN-γ ELISPOT.

(A)All the peptides assayed were recognized by spleen cells from T. cruzi-infected A2 transgenic mice (25). (B)Number of annotated T. cruzi genes containing indicated epitopes (13). (C)Number of proteins containing indicated epitopes identified in T. cruzi proteome (59). (D)Number of alleles of the HLA-A2 supertype bound. (E)Mean values was obtained from responders subjects. (*) P = 0.04 vs. G2/G3 (Fisher's exact test).