RNA-sequencing facilitates Quantitative Analysis of Wild Type and Tsg101 Transgenic cardiac transcriptomes

Tumor susceptibilty gene 101 (Tsg101) is a key member of the endosomal sorting complex required for transport (ESCRT), that has divergent roles in carcinogenesis, ubiquitination, endosomal trafficking, virus budding, cytokinesis, cell survival and proliferation. The goal of this study is to compare cardiac transcriptome profiles of wild-type (WT) and cardiac-specific Tsg101 Transgenic (TG) mice. Overall design: Cardiac mRNA profiles of 8-week old wild-type (WT) and Tsg101 Transgenic mice were generated by RNA sequencing using standard Illumina