Intra-class correlation coefficient (ICC) is highest amongst the CANARY classes representing most invasive ADC features.

Intra-class correlation coefficient (ICC), a measure of agreement of quantitative assessments made by different observers evaluating the same quantity, was calculated for each CANARY class, the VIRO group, and the average (Avg.) of all classes. An ICC of 0.8–1 reflects high agreement between users. These calculations were performed for the VUMC/TVHS and the Mayo cohorts, as well as for each subgroup of patients scanned by a particular CT scanner (GE Medical Systems, Philips, and Siemens). ICCs and 95% CI for each voxel class are shown below. The number of patients within each cohort is listed in parentheses.