The global hubs of the human brain functional network.

The hub regions (Nbc(i)>mean+SD) are listed in a decreasing order of their relative node betweenness centrality and further classified into association, primary, limbic/paralimbic and subcortical regions as described by Mesulam (2000). Nbc(i), K(i), C(i) and L(i) denote the relative node betweenness, degree, clustering coefficient and shortest path length of node i, respectively. The Module column denotes the functional modules that the hub regions belong to, and the Role column denotes the roles that the hub regions play in terms of their intra- and inter-module connectivity patterns (See Materials and Methods). R: right; L: left. For the description of the abbreviations, see Table S1.