Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment. Telomere dysfunction cooperates with epigenetic alterations to impair murine embryonic stem cell fate commitment

This study demonstrates a specific cooperativity between perturbations in histone methylation and eroded telomeres to destabilize the differentiation of murine embryonic stem cells. Overall design: Murine embryonic stem cells of two different genotypes (WT or Tert-/-) were subjected to differentiation, and treated with compounds that modulated histone H3K27 tri-methylation to assess their impact upon the differentiation response