Changes imposed by Clostridium difficile infection on the human gut microbiome

Clostridium difficile-associated diarrhoea (CDAD) is caused by C. difficile toxins A and B and represents a serious health problem. In this study, we analyzed the metabolic changes associated to C. difficile infection in the human gut microbiota and its relation with the production or not of toxins A and B. In addition, we sequenced the amplicons of the 16SrDNA gene of the fecal samples to explore the effect of Clostridium difficile infection and toxin production on the intestinal microbial composition.