HLA haplotypes and genotypes in clustering autoimmunity.

HLA class II risk groups, haplotypes and genotypes were compared between children with multiple autoimmune diseases and those with T1D only, as well as children from autoimmune families and children without any additional autoimmune diseases in the family. (Autoimmune families: ≥4 diagnoses of autoimmune diseases (T1D or other) and/or ≥3 different autoimmune diseases (T1D or other) in first- and/or second-degree relatives and/or the index child). For the comparison of risk groups, a joint P value is shown. Five children did not have any information on their HLA genetics and were thus excluded from this analysis; none of the five had other autoimmune diseases and one came from an autoimmune family.