Activities of mitochondrial respiratory chain complexes in 12-month-old PARK2−/− and wild type mice.

Striatum = post-nuclear supernatants from striatum, Midbrain = crude mitochondrial pellet from ventral midbrain, Cortex = crude mitochondrial pellet from occipital cortex; complex I = rotenone sensitive NADH ubiquinone oxidoreductase, complex II = succinate ubiquinone oxidoreductase, combined II+III = succinate cytochrome c oxidoreductase, complex III = antimycin sensitive ubiquinol cytochrome c oxidoreductase, complex IV = cytochrome c oxidase, complex V = F1F0 ATPsynthase; complex V assay requires mitochondrial preparation and was therefore not performed on striatal post-nuclear supernatants; data are expressed as nanomoles/minute and mg proteins and as means ± SD; each series of values represents 7 independent samples from each genotype.