Fasting potentiates the anticancer activity of Crizotinib
收藏官方服务:
资源简介:
Fasting potentiates the anticancer activity of Crizotinib
应用场景:
创建时间:
2016-07-03
相关数据集
Protein synthesis inhibitors stimulate MondoA transcriptional activity by driving accumulation of glucose 6-phosphate
BACKGROUND: Protein synthesis is regulated by the availability of amino acids, the engagement of growth factor signaling pathways and ATP levels sufficient to support translation. Crosstalk between th
NIAID Data Ecosystem70
Cholesterol homeostasis modulates platinum sensitivity in human ovarian cancer
Here we show that platinum-resistant ovarian cancer cells also show reduced cholesterol biosynthesis, and mostly rely on uptake of exogenous cholesterol for their needs. Expression of FDPS and OSC, en
NIAID Data Ecosystem50
Arginine starvation elicits chromatin leakage and cGAS-STING activation via epigenetic silencing of metabolic and DNA-repair genes [ChIP-seq]
One of the most common metabolic defects of cancer cells is the deficiency in arginine synthesis due to suppressed expression of argininosuccinate synthetase 1 (ASS1) which renders cancer cells auxotr
NIAID Data Ecosystem20
Non-Toxic Metabolic Management of Metastatic Cancer in VM Mice: Novel Combination of Ketogenic Diet, Ketone Supplementation, and Hyperbaric Oxygen Therapy
The Warburg effect and tumor hypoxia underlie a unique cancer metabolic phenotype characterized by glucose dependency and aerobic fermentation. We previously showed that two non-toxic metabolic therap
NIAID Data Ecosystem70
α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer [RNA-seq I]. α-Ketoglutarate attenuates Wnt signaling and drives differentiation in colorectal cancer [RNA-seq I]
Genetic-driven deregulation of the Wnt pathway is crucial but not sufficient for colorectal cancer (CRC) tumourigenesis. Here, we show that environmental glutamine restriction further augments Wnt sig
NIAID Data Ecosystem40



