Neurophilin interactions with VEGF and VEGFR

The plasma membrane-associated Neuropilin receptors NRP-1 and -2 bind some of the VEGF proteins and associate with VEGF receptor proteins. NRP-1 binds VEGF-A165, -B, and PLGF-2; NRP-2 also binds VEGF-A165 and PLGF-2, as well as VEGF-A145 and -C. The Neurolipin receptors appear to act as cofactors for the VEGF receptors, increasing their affinities for specific VEGF ligands, although the importance of this function in vivo remains unclear (Neufeld et al. 2002).

神经突触膜相关神经元蛋白受体NRP-1和NRP-2能与某些VEGF蛋白结合，并与VEGF受体蛋白相互作用。NRP-1能与VEGF-A165、-B以及PLGF-2结合；NRP-2亦能与VEGF-A165、PLGF-2相结合，此外还能与VEGF-A145和-C结合。神经元蛋白受体似乎充当VEGF受体的辅助因子，增强其对特定VEGF配体的亲和力，尽管这种功能在体内的意义尚不明确（Neufeld等，2002年）。