B-ALL NK-cell activation CRISPR screen

NIAID Data Ecosystem2026-05-02 收录

肿瘤免疫学

功能基因组筛选

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP529449 数据链接链接失效反馈

官方服务：

资源简介：

Investigated NK-cell interactions with B-cell acute lymphoblastic leukemia (B-ALL) by whole transcriptome CRISPR CAS9 screen using Yusa library.

创建时间：

2025-09-01

Association between HPK1 expression and T-cell exhaustion. Association between HPK1 expression and T-cell exhaustion

肿瘤免疫学

T细胞耗竭

We aimed to investigate the association between HPK1 expression and exhausted status of tumor. Overall design: Bulk RNA-seq was performed on fresh-frozen tissue samples of renal cell carcinoma.

NIAID Data Ecosystem60

Genomic Variations and Immune-related Features in Undifferentiated Carcinoma with Osteoclast-like Giant Cells of the Pancreas: a single center retrospective cohort study

基因组学

肿瘤免疫学

Background: Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas (UCOGCP) was a rare malignancy. Literature on UCOGCP was limited, especially about mutation landscape and immune

NIAID Data Ecosystem40

Epinephelus malabaricus Genome and Transcriptome data

鱼类基因组学

功能基因组筛选

Chromosome level genome assembly of the Malabar grouper (Epinephelus malabaricus) based on PacBio HiFi data and PhaseGenomics scaffolding. This project contains all the raw data, including: 1) PacBio

NIAID Data Ecosystem30

Transcriptome analysis of tumor infiltrating NK and T cells in CT26-bearing BALB/C mice

肿瘤免疫学

肿瘤浸润淋巴细胞

CT26 tumors were implanted subcutaneously into syngeneic BALB/C mice and allowed to grow for 15-25 days. Tumors were collected, mechanically dissociated, and immune cells enriched using Percoll gradie

NIAID Data Ecosystem60

活化的CD4+T细胞赋予了肿瘤巨噬细胞产生CXCL10的能力数据集

肿瘤免疫学

细胞信号传导

此数据集以压缩包的形式呈现，包括3个word文件：1个word文档的整合图和2个对应的原始数据。肝癌中活化CD4+ T细胞产生大量IFN-γ（图5A-D）。这些活化T细胞主要是Th1亚群（图5E）。活化CD4+ T细胞通过IFN-γ促进肿瘤巨噬细胞产生CXCL10（图5F和G）。荷瘤小鼠模型中去除CD4+ T细胞或阻断IFN-γ信号废除肿瘤巨噬细胞CXCL10的产生（图5H-J）。

国家人口健康科学数据中心40

B-ALL NK-cell activation CRISPR screen

资源简介：

相关数据集