LCLF1.0 Data

In this study, we investigated ad libitum food intake of 20 healthy adult volunteers who each completed a 4-week stay at the National Institutes of Health (NIH). During their stay, they consumed a low-carbohydrate, high-fat (LCHF) diet and a low-fat, high-carbohydrate (LFHC) diet for 2 weeks each, in random order. We collected information about energy intake and metabolic changes in response to the two test diets. The test diets were presented to subjects in amounts exceeding their daily energy requirements, and subjects were instructed to eat as much or as little of each diet as desired. This study implemented 7-day rotating menus for each test diet. The diets were matched for presented calories and protein, but the LCHF diet was low in carbohydrate (~10% of calories) and high in fat (~75% of calories) whereas the LFHC diet was high in carbohydrates (~75% of calories) and low in fat (~10% of calories). The two test diets had a common foundation of vegetables with low amounts of digestible carbohydrates such as lettuce, spinach, kale, cabbage, cauliflower, zucchini, tomato, asparagus, broccoli, peppers, brussels sprouts, and green beans. The LCHF diet included meat, poultry, fish, eggs, dairy, and nuts. The LFHC diet included legumes, rice, root vegetables, soy products, corn, lentils, peas, whole grains, bread, and fruit. The test diets were designed using a standard computerized nutrition database, and blood samples were collected from the subjects.]]>
Inclusion Criteria: 1. Adults age 18-50 years, male or female 2. Weight stable (< ± 5 % over past 6 months) as determined by volunteer report 3. Body mass index (BMI) ≥ 20kg/m2 4. Body weight ≥ 53 kg 5. Able to complete daily bouts of stationary cycling at a moderate rate and intensity with a heart rate (HR) ≥ 0.3×(220-age-HRrest)+HRrest but not exceeding 0.4×(220-age-HRrest)+HRrest and no signs of arrhythmiaExclusion Criteria: 1. Evidence of metabolic or cardiovascular disease, or disease that may influence metabolism (e.g. cancer, diabetes, thyroid disease) 2. Taking any prescription medication or other drug that may influence metabolism (e.g. diet/weight-loss medication, asthma medication, blood pressure medication, psychiatric medications, corticosteroids, or other medications at the discretion of the Principal Investigator (PI) and/or study team) 3. Positive pregnancy test or lactation as determined by volunteer report (women only) 4. Participating in a regular exercise program (> 2h/week of vigorous activity) as determined by volunteer report 5. Hematocrit < 37% (women only) 6. Hematocrit < 40% (men only) 7. Caffeine consumption > 300 mg/day as determined by volunteer report]]>