Role of Gα(olf) in Familial and Sporadic Adult-Onset Primary Dystonia. Homo sapiens

Gene expression studies were performed to identify pathways possibly dysregulated by mutant in the gene Gα(olf). These experiments employed RNA derived from lymphoblastoid cell lines established for 4 affected carriers and 4 non-carriers. In comparison to endogenous control and other dystonia-associated genes, GNAL was expressed at relatively low levels in lymphoblastoid cell lines. Overall design: Comparison of whole blood expression profiles of mutation carrying dystonia patients with normal controls