Gut Microbiome, Sleep and Pain in Patients with Chronic Low Back Pain

The purpose of this study is to determine the presence of alterations in the diversity and/or composition of the microbiome that could help identify underlying mechanisms in the pain-sleep cycle. Among many pathways postulated, the inflammatory pathway is one possible link connecting the microbiome to pain and sleep. Understanding the mechanisms underlying chronic low back pain (CLBP) can lead to further clarify the complexities that underlie CLBP which can lead to better treatment strategies, help explore innovative diagnostic methods, and interventions such as use of pro-biotics and pre-biotics to improve sleep and pain.