Direct ex vivo analyses of HLA-DR1 transgenic mice reveal an exceptionally broad pattern of immunodominance in the primary HLA-DR1-restricted CD4 T-cell response to influenza virus hemagglutinin.
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The authors provided accession number AAP34324 for source of this epitope. A Pepscan analysis was performed using overlapping 18-mers spanning the entire HA protein to assess specificity of influenza-specific CD4 T cells. This epitope was identified as immunodominant among CD4 T cells from infected HLA-DR1 transgenic mice.
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2007-01-01



