T3-Dependent Transcriptional Programming by TR-beta Requires SWI/SNF Chromatin Remodelers (ATAC-Seq)

We used an integrated genomics approach to profile and characterize the cistrome of TR-beta, map changes in chromatin accessibility, and capture the transcriptomic changes in response to T3 in a normal thyroid cell line. Our data demonstrates that T3 promotes significant shifts in TR-beta genomic occupancy, which are associated with differential chromatin accessibility, and differential recruitment of SWI/SNF chromatin remodelers. Overall design: Epigenetic and transcriptomic anlaysis a of thyroid hormone receptor beta binding and regulation of chormatin accessibility in normal thyroid cells in the presence and absence of thyroid hormone.