MET phosphorylates PTK2

Activated MET phosphorylates PTK2 (FAK1) at tyrosine residue Y194. Phosphorylation of PTK2 at Y194 facilitates SRC-mediated phosphorylation of PTK2 at Y577, but it has not been tested whether MET-mediated phosphorylation precedes SRC binding. MET may also phosphorylate PTK2 at Y5, although no functional significance of Y5 phosphorylation has been demonstrated. Activated EGFR and PDGFR can also phosphorylate PTK2 at Y5 and Y194 (Chen et al. 2011).

激活的MET蛋白在酪氨酸残基Y194处磷酸化PTK2（FAK1）。PTK2在Y194位点的磷酸化有利于SRC介导的PTK2在Y577位点的磷酸化，然而，尚未证实MET介导的磷酸化是否在SRC结合之前发生。MET还可能在Y5位点磷酸化PTK2，尽管Y5位点的磷酸化尚未显示出其功能意义。激活的EGFR和PDGFR也能在Y5和Y194位点磷酸化PTK2（Chen等，2011年）。