Patient in mechanical ventilation in ICU (12/04/17 - 05/04/18)

Purpose: To compare the predictive ability of the most used system scores Sequential
Organ Failure Assessment (SOFA), Acute Physiology and Chronic Health Evaluation
(APACHE) II and Simplified Acute Physiology Score (SAPS) II for mortality in
mechanically ventilated (MV) patients in ICU (Intensive Care Unit).

We conducted a single-center prospective observational study. It was realized in
8-bed ICU in a tertiary University Hospital in South Brazil during 12/04/17 - 05/04/18. In this period 85 patients were admitted in ICU and 60 patients were submitted to mechanical ventilation for 48 hours or more.

Patients admitted to the ICU submitted to mechanical ventilation for 48 hours or more
during this period were included. Patients not submitted to MV or with less than 48 hours
were excluded. 60 patients were in MV for 48 hours or more, however 2 of them were
transferred to another ICU and thus was not included in this study. Data were collected
daily, by a single researcher, and in a longitudinal way to obtain variables of the medical,
physiological and laboratory history.
Database was divided in variables of patients' comorbidities: chronic obstructive
pulmonary disease, chronic cardiac arrhythmia, ischemic heart disease, sleep apnea
syndrome, asthma, neuromuscular and chest wall diseases, previous infections, neoplasia,
sepsis, stroke, diabetes, other endocrine diseases; physiological variables: vital
parameters (respiratory rate, pulse, mean artery pressure, axillary temperature),
oxygenation parameters (PaO2/FIO2 ratio, PCO2, AaDO2, arterial pH, mechanical
ventilation, Non-invasive ventilation) and acute physiological factors (use of
vasopressor/inotropic, ARDS, dialysis, urine output, water balance, diet, Glasgow coma
scale); laboratory variables: blood count, cultures, bilirubins, creatinine, urea, potassium,
sodium, bicarbonate, albumin, glucose. It was also collected by the researcher daily the
appearance of the following complications: postoperative infections in the ICU
(pneumonia, abdominal and urinary sepsis and wound infections), hematological
complications (thrombocytopenia <100,000) and renal complications (urine output
<500ml or serum creatinine >170 μmol/l or dialysis for acute renal failure).
Demographic data, diagnosis of patient admission, duration of ventilation
mechanics, length of stay in the ICU and total hospital stay, survivors, non-survivors
were obtained and classified within the study. The value of variables that are part of the
system scores were the most abnormal value for each variable during the last 24 hours.
APACHE II, SAPS II and SOFA were calculated on the day of admission and on the last
day in MV.

VM1: All patients on the first day of MV
VM2: All patients on the last day of MV
vm10: Survivors on the first day of MV
vm11: Non-survivors on the first day of MV
vm20: Survivors on the last day of MV
vm21: Non-survivors on the last day of MV