Data accompanying dissertation Continuous Chromatography of Biopharmaceuticals - Next Generation Process Development

This folder contains data generated during the PhD project: Biopharmaceutical Continuous Chromatography - Next Generation Process DevelopmentBy Tiago Picanço Castanheira da Silva in Delft University of TechnologySupervisors: Marcel Ottens and Michel EppinkDepartment of Biotechnology, Section of Bioprocess Engineering When using the data, please refer using:<strong>Silva <em>et al.</em> (2022)</strong> Small, smaller, smallest: Miniaturization of chromatographic process development (doi: 10.1016/j.chroma.2022.463451), <strong style="background-color:rgb(255, 250, 234);">Silva <em>et al.</em> (2023) </strong>Digital Twin in High Throughput Chromatographic Process Development for Monoclonal Antibodies (under submission), <strong style="background-color:rgb(255, 250, 234);">Silva <em>et al.</em> (2023) </strong>Integrated Continuous Chromatography for Capture and Polishing at High Protein Load (under submission).<br>The data is divided into 3 folders, each referring to one chapter in the dissertation:- Chapter 4: Small, smaller, smallest: Miniaturization of chromatographic process development.- Chapter 5: Digital Twin in High Throughput Chromatographic Process Development for Monoclonal Antibodies.- Chapter 6: Integrated Continuous Chromatography for Capture and Polishing at High Protein Load.Within each folder, the data is organized in a folder corresponding to the chapter content to which it refers to (figure and tables).

本文件夹包含代尔夫特理工大学生物技术系生物过程工程教研室的Tiago Picanço Castanheira da Silva在其博士研究项目"生物制药连续色谱（Continuous Chromatography）——下一代工艺开发"中生成的研究数据。本项目指导教师为Marcel Ottens与Michel Eppink。
使用本数据集时，请引用如下文献：<strong>Silva 等人(2022)</strong> 《更小，最小：色谱（Chromatography）工艺开发的微型化》（DOI: 10.1016/j.chroma.2022.463451），<strong style="background-color:rgb(255, 250, 234);">Silva 等人(2023)</strong> 《单克隆抗体（Monoclonal Antibodies）高通量色谱工艺开发中的数字孪生（Digital Twin）》（已投稿），<strong style="background-color:rgb(255, 250, 234);">Silva 等人(2023)</strong> 《高蛋白负载下用于捕获与纯化的集成连续色谱技术》（已投稿）。
本数据集共分为3个文件夹，分别对应博士论文的3个章节：
- 第4章：《更小，最小：色谱工艺开发的微型化》
- 第5章：《单克隆抗体高通量色谱工艺开发中的数字孪生》
- 第6章：《高蛋白负载下用于捕获与纯化的集成连续色谱技术》
各章节文件夹内，数据将按照对应章节的内容（包含图表与表格）进行分类存储。