Gene Expression of Small Cell Carcinoma of the Ovary-Hypercalcemic Type (SCCOHT)

Small cell carcinoma of the ovary-hypercalcemic type (SCCOHT) is a rare and aggressive form of ovarian cancer afflicting young women at a median age of 24 years. SCCOHTs are characterized by loss of protein expression of SWI/SNF chromatin remodeling ATPases SMARCA4 and SMARCA2 through mutation and epigenetic silencing, respectively. This study aims to establish gene expression profiles of this cancer through RNA-Seq of fourteen pathologically confirmed cases of SCCOHT tumors.]]>
Diagnosis of SCCOHT was confirmed by pathology review for dual negative staining for SMARCA4 and SMARCA2.]]>
February 2011 – First patient consents to studyAugust 2011 – First frozen samples received at TGen for studyMarch 2012 – RNA-Seq and data analysis performed (TGEN-A and TGEN-B) September 2018 – RNA-Seq on additional cohort performed (TGEN-F, TGEN-G, TGEN-H, TGEN-I, TGEN-J) January 2020 – Sequencing data from UBC-A and UBC-B were received at TGen ]]>