Resilience and susceptibility in a mouse model of immune-mediated neurodevelopmental disorders

We identify and characterize subgroups of isogenic mouse offspring exposed to identical maternal immune activation induced by gestational administration of the viral mimetic, poly(I:C). We demonstrate that offspring with manifest impairments in social behavior, sensorimotor gating and working memory (“susceptible” offspring) differ from asymptomatic (“resilient” offspring) in terms of their transcriptional profiles in cortical and subcortical brain regions, while displaying only subtle differences in brain morphometry We perfromed next-generation RNA sequencing in the medial prefreontal cortex and amygdala in subgroup of behvairally characterized offspring ( n=3 resilient, n=3 susceptible and n=3 control offspring)