Genome-wide analysis of RB and p130 binding in human diploid fibroblasts
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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资源简介：
The action of RB as a tumor suppressor has been difficult to define, in part, due to the redundancy of the related proteins p107 and p130. By coupling advanced RNAi technology with a genome wide analysis of gene expression and RB chromatin binding, we identified a unique and specific activity of RB in repressing DNA replication as cells exit the cell cycle into senescence, a tumor suppressive program.
提供机构：
Memorial Sloan Kettering
创建时间：
2022-02-20
