Establishment of hTERT immortalized mouse cardiosphere derived cell line
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE131765
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The analysis showed differences of transcriptomes between primary CDCs and immortalized CDCs as well as revealed TGF-β inhibitor-SB431542 treatment induced expression changes. We identified hTERT immortalization could result the cell proliferation and cell cycle related genes upregulation in iCDC. KEGG results demonstrated that TGF-β inhibitor SB431542 treatment could inhibit cardiomyopathy-related pathway which indicate TGF-β signaling pathway may serve as new target for cardiomyopathy therapy, and iCDC could be used as a heart-related chemicals screening. Primary CDCs, iCDCs and SB432542-treated iCDCs mRNA profiles were generated by deep sequencing, in triplicate, using Illumina HiSeq2000.
创建时间：
2022-02-18
